Current Awareness and Knowledge of Heavy Metals A Short Review
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Abstract
This review discusses public health hazards associated with environmental heavy metals, focusing on those that are especially toxic and persistent: lead, mercury, cadmium, arsenic, chromium, copper, nickel, and zinc. Most of the discussion in this review is devoted to identifying potential routes of exposure and the potential health effects that these metals might pose. In addition, the effectiveness of educational programs is considered, together with demographic factors influencing public knowledge. The methodology includes a detailed literature review to highlight gaps in knowledge and the impacts of the education process. The preliminary findings show very limited knowledge among the public about the risks from toxic metals, especially among children and people working in the industrial sectors. Notwithstanding the aforementioned educational initiatives, there is still a greater need for further intervention strategies to increase awareness and ensure safety. Further, the review shows a lack of concerted efforts on strategies aimed at reducing heavy metal toxicity, including chelation therapy, phytoremediation, and advanced techniques like electro sorption and nanotechnology. The text further examines the efficacy of dietary selections and supplements as natural detoxification techniques that could assist the body in expelling these harmful substances. The study thus concludes emphatically that mitigating the risks of exposure to heavy metals requires increasing public awareness and education, imposing strict regulations on emissions from industries, and involving the community. Policymakers, educators, and health professionals must be unified on a single platform to spread awareness about effective remediation and natural detoxification methodologies. Heavy metals largely threaten human health and ecosystems, so the protection of human health and the maintenance of ecosystems require a comprehensive approach.
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Copyright (c) 2024 Maghchiche Abdelhak, Meghchiche Nourelhouda (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Maghchiche Abdelhak, University of Batna 2, Batna - Algeria.
Analytical Chemistry Laboratory,
Pharmacy Department, University of Batna 2, Batna - Algeria.
Meghchiche Nourelhouda, University of Batna 2, Batna - Algeria.
Analytical Chemistry Laboratory,
Pharmacy Department, University of Batna 2, Batna - Algeria.
Abd Elnabi, M. K., Elkaliny, N. E., Elyazied, M. M., Azab, S. H., Elkhalifa, S. A., Elmasry, S., ... & Mahmoud, Y. A. G. (2023). Toxicity of heavy metals and recent advances in their removal: A review. Toxics, 11(7), 580.
https://doi.org/10.3390/toxics11070580
Abdel-Rahman, G. (2022). Heavy metals, definition, sources of food contamination, incidence, impacts, and remediation: A literature review with recent updates. Egyptian Journal of Chemistry, 65(1), 419-437. https://doi.org/10.21608/ejchem.2022.153545.5838
Abu Farha, R., Alzoubi, K. H., Khabour, O. F., & Mukattash, T. L. (2020). Factors influencing public knowledge and willingness to participate in biomedical research in Jordan: A national survey. Patient Preference and Adherence, 14, 1373-1379. https://doi.org/10.2147/PPA.S265668
https://doi.org/10.2147/PPA.S261903
Afzal, A., & Mahreen, N. (2024). Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock. Frontiers in Pharmacology, 15, 1375137. https://doi.org/10.3389/fphar.2024.1375137
https://doi.org/10.3389/fphar.2024.1375137
Agnew, U. M., & Slesinger, T. L. (2020). Zinc toxicity. Encyclopedia of Environmental Health, 5, 407-411. https://doi.org/10.1016/B978-0-12-409548-9.12131-4
Aalami, A. H., Hoseinzadeh, M., Hosseini Manesh, P., Jiryai Sharahi, A., & Kargar Aliabadi, E. (2022). Carcinogenic effects of heavy metals by inducing dysregulation of microRNAs: A review. Molecular Biology Reports, 49(12), 12227-12238. https://doi.org/10.1007/s11033-022-07969-8
https://doi.org/10.1007/s11033-022-07897-x
Bakulski, K. M., Seo, Y. A., Hickman, R. C., Brandt, D., Vadari, H. S., Hu, H., & Park, S. K. (2020). Heavy metals exposure and Alzheimer's disease and related dementias. Journal of Alzheimer's Disease, 76(4), 1215-1242. https://doi.org/10.3233/JAD-200964
https://doi.org/10.3233/JAD-200964
Briffa, J., Sinagra, E., & Blundell, R. (2020). Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon, 6(9), e04834. https://doi.org/10.1016/j.heliyon.2020.e04834
https://doi.org/10.1016/j.heliyon.2020.e04834
Carmona, A., Roudeau, S., & Ortega, R. (2021). Molecular mechanisms of environmental metal neurotoxicity: A focus on the interactions of metals with synapse structure and function. Toxics, 9(9), 198. https://doi.org/10.3390/toxics9090198
https://doi.org/10.3390/toxics9090198
Das, S., Sultana, K. W., Ndhlala, A. R., Mondal, M., & Chandra, I. (2023). Heavy metal pollution in the environment and its impact on health: Exploring green technology for remediation. Environmental Health Insights, 17, 11786302231201259. https://doi.org/10.1177/11786302231201259
https://doi.org/10.1177/11786302231201259
Das, T. K., & Poater, A. (2021). Review on the use of heavy metal deposits from water treatment waste towards catalytic chemical syntheses. International Journal of Molecular Sciences, 22(24), 13383. https://doi.org/10.3390/ijms222413383
https://doi.org/10.3390/ijms222413383
Engwa, G. A., Ferdinand, P. U., Nwalo, F. N., & Unachukwu, M. N. (2019). Mechanism and health effects of heavy metal toxicity in humans. Poisoning in the Modern World-New Tricks for an Old Dog, 10, 70-90. https://doi.org/10.2174/9781681084018119010007
Gajbhiye, D. R., & Wadnerwar, N. N. (2021). Assessment of awareness regarding heavy metal toxicity in schoolchildren. Journal of Pharmaceutical Research International, 33(37B), 111-116. https://doi.org/10.9734/jpri/2021/v33i3731053
https://doi.org/10.9734/jpri/2021/v33i37B32028
Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B. B., & Beeregowda, K. N. (2014). Toxicity, mechanism, and health effects of some heavy metals. Interdisciplinary Toxicology, 7(2), 60-72. https://doi.org/10.2478/intox-2014-0009
https://doi.org/10.2478/intox-2014-0009
Järup, L. (2003). Hazards of heavy metal contamination. British Medical Bulletin, 68(1), 167-182. https://doi.org/10.1093/bmb/ldg032
https://doi.org/10.1093/bmb/ldg032
Jyothi, N. R. (2020). Heavy metal sources and their effects on human health. In Heavy Metals-Their Environmental Impacts and Mitigation (pp. 1-12). Nova Science Publishers.
Khoi Quan, N., & Liamputtong, P. (2023). Social surveys and public health. In Handbook of Social Sciences and Global Public Health (pp. 1-19). Springer International Publishing. https://doi.org/10.1007/978-3-030-39472-1_1
https://doi.org/10.1007/978-3-030-39472-1_1
Kim, H. S., Kim, Y. J., & Seo, Y. R. (2015). An overview of carcinogenic heavy metal: Molecular toxicity mechanism and prevention. Journal of Cancer Prevention, 20(4), 232-237. https://doi.org/10.15430/JCP.2015.20.4.232
https://doi.org/10.15430/JCP.2015.20.4.232
Kim, J. J., Kim, Y. S., & Kumar, V. (2019). Heavy metal toxicity: An update of chelating therapeutic strategies. Journal of Trace Elements in Medicine and Biology, 54, 226-231. https://doi.org/10.1016/j.jtemb.2019.01.007
https://doi.org/10.1016/j.jtemb.2019.01.007
Kumar, M., Gogoi, A., Kumari, D., Borah, R., Das, P., Mazumder, P., & Tyagi, V. K. (2017). Review of perspective, problems, challenges, and future scenario of metal contamination in the urban environment. Journal of Hazardous, Toxic, and Radioactive Waste, 21(4), 04017007. https://doi.org/10.1061/(ASCE)HZ.2153-5515.0000384
https://doi.org/10.1061/(ASCE)HZ.2153-5515.0000384
Kumar, N. (Ed.). (2024). Heavy metal remediation: Sustainable nexus approach. Springer Nature. https://doi.org/10.1007/978-3-030-70888-3
https://doi.org/10.1007/978-3-031-53688-5
Mahmoud, N., Al-Shahwani, D., Al-Thani, H., & Isaifan, R. J. (2023). Risk assessment of the impact of heavy metals in urban traffic dust on human health. Atmosphere, 14(6), 1049. https://doi.org/10.3390/atmos14061049
https://doi.org/10.3390/atmos14061049
Manivannan, B., Yegambaram, M., Supowit, S., Beach, T. G., & Halden, R. U. (2019). Assessment of persistent, bioaccumulative and toxic organic environmental pollutants in liver and adipose tissue of Alzheimer's disease patients and age-matched controls. Current Alzheimer Research, 16(11), 1039-1049. https://doi.org/10.2174/15672050176661903191203
https://doi.org/10.2174/1567205016666191010114744
Martin, S., & Griswold, W. (2009). Human health effects of heavy metals. Environmental Science and Technology Briefs for Citizens, 15(5), 1-6. https://doi.org/10.1021/es9000259
Martin, N., Harun, M., Nga'nga, M., & Gerald, M. (2020). Using cilantro (Coriandrum sativum) to remove cadmium from contaminated water. World Environment, 10(1), 1-9. https://doi.org/10.20944/preprints202007.0230.v1
https://doi.org/10.20944/preprints202007.0230.v1
Mitra, S., Chakraborty, A. J., Tareq, A. M., Emran, T. B., Nainu, F., Khusro, A., ... & Simal-Gandara, J. (2022). Impact of heavy metals on the environment and human health: Novel therapeutic insights to counter the toxicity. Journal of King Saud University-Science, 34(3), 101865. https://doi.org/10.1016/j.jksus.2022.101865
https://doi.org/10.1016/j.jksus.2022.101865
Mehrandish, R., Rahimian, A., & Shahriary, A. (2019). Heavy metals detoxification: A review of herbal compounds for chelation therapy in heavy metals toxicity. Journal of Herbmed Pharmacology, 8(2), 69-77. https://doi.org/10.15171/jhp.2019.10
https://doi.org/10.15171/jhp.2019.10
Niede, R., & Benbi, D. K. (2022). Integrated review of the nexus between toxic elements in the environment and human health. AIMS Public Health, 9(4), 758-787. https://doi.org/10.3934/publichealth.2022.4.758
https://doi.org/10.3934/publichealth.2022052
Paul, B. T., Clement, G. Y., Anita, K. P., & Dwayne, J. S. (2012). Heavy metals toxicity and the environment. EXS, 101, 133-164. https://doi.org/10.1007/978-3-642-23426-3_7
Plum, L. M., Rink, L., & Haase, H. (2010). The essential toxin: Impact of zinc on human health. International Journal of Environmental Research and Public Health, 7(4), 1342-1365. https://doi.org/10.3390/ijerph7041342
https://doi.org/10.3390/ijerph7041342
Prakash, P. (2023). Nano-phytoremediation of heavy metals from soil: A critical review. Pollutants, 3(3), 360-380. https://doi.org/10.3390/pollutants3030024
https://doi.org/10.3390/pollutants3030024
Rajkumar, V., Lee, V. R., & Gupta, V. (2020). Heavy metal toxicity. Environmental Toxicology and Pharmacology, 79, 103367. https://doi.org/10.1016/j.etap.2020.103367
Ravichandran, S. (2011). Possible natural ways to eliminate toxic heavy metals. International Journal of Chemtech Research, 3(4), 1886-1890. https://www.sphinxsai.com/2021/ijcrpp/22.pdf
Sabath, E., & Robles-Osorio, M. L. (2012). Renal health and the environment: Heavy metal nephrotoxicity. Nefrología (English Edition), 32(3), 279-286. https://doi.org/10.3265/Nefrologia.pre2012.May.11729
Senanu, L. D., Kranjac-Berisavljevic, G., & Cobbina, S. J. (2023). The use of local materials to remove heavy metals for household-scale drinking water treatment: A review. Environmental Technology & Innovation, 29, 103005. https://doi.org/10.1016/j.eti.2023.103005
https://doi.org/10.1016/j.eti.2023.103005
Shi, D., Xie, C., Wang, J., & Xiong, L. (2021). Changes in the structures and directions of heavy metal-contaminated soil remediation research from 1999 to 2020: A bibliometric & scientometric study. International Journal of Environmental Research and Public Health, 18(14), 7358. https://doi.org/10.3390/ijerph18147358
https://doi.org/10.3390/ijerph18147358
Sripada, K., & Lager, A. M. (2022). Interventions to reduce cadmium exposure in low-and middle-income countries during pregnancy and childhood: A systematic review. Journal of Global Health, 12, 06021. https://doi.org/10.7189/jogh.12.06021
https://doi.org/10.7189/jogh.12.04089
Tchounwou, P. B., Yedjou, C. G., Patlolla, A. K., & Sutton, D. J. (2012). Heavy metal toxicity and the environment. In Molecular, Clinical and Environmental Toxicology: Volume 3: Environmental Toxicology (pp. 133-164). Springer. https://doi.org/10.1007/978-3-7643-8340-4-7
https://doi.org/10.1007/978-3-7643-8340-4_6
Vardhan, K. H., Kumar, P. S., & Panda, R. C. (2019). A review on heavy metal pollution, toxicity and remedial measures: Current trends and future perspectives. Journal of Molecular Liquids, 290, 111260. https://doi.org/10.1016/j.molliq.2019.111260